What is bilastine used for?
Bilastine is a selective, second-generation H1-antihistamine. It was first approved in the European Union in 2010 for the symptomatic treatment of allergic rhinoconjunctivitis (seasonal and perennial) and urticaria in patients aged 12 years or older, and is now available in approximately 100 countries worldwide8.
Can you take bilastine everyday?
Clinical studies sponsored by the manufacturer have shown that bilastine 20 mg once daily is as efficacious as other nonsedating antihistamines in allergic rhinoconjunctivitis and chronic urticaria in individuals from 12 and 18 years of age, respectively.
Is bilastine and Bilaxten same?
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives). It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine.
Which is better cetirizine or bilastine?
Bilastine is more effective than cetirizine at limiting the early allergic response, according to the results of a study in volunteers. Volunteers received a single oral dose of bilastine 20 mg, cetirizine 10 mg, or placebo, before provocation of a cutaneous wheal and flare response.
Is bilastine safe for kidneys?
Although exposure to bilastine was higher in renally impaired subjects, it remained well within the safety margins, thus allowing the conclusion that a 20-mg daily dose can be safely administered to subjects with different degrees of renal insufficiency without the need for dose adjustments.
Is bilastine a steroid?
Bilastine is an antihistamine that is used to relieve the symptoms of allergic rhinoconjunctivitis (sneezing, itchy nose, nasal secretion, nasal congestion and red, streaming eyes) and other forms of allergic rhinitis. It can also be used to treat itchy skin rashes (wheals or urticaria).
What are the side effects of bilastine?
Side Effects of BILASTINE
- Abdominal pain.
- Headache.
- Dizziness.
- Dry mouth.
- Sore throat.
- Nausea.
Is bilastine a strong antihistamine?
It belongs to piperidine derivatives and is not structurally derived from any other currently available antihistamines. Bilastine exerts a potent and specific H1-antihistamine activity. Bilastine is an H1 receptor inverse agonist, like other antihistamines already available.
How safe is bilastine?
Conclusion: Bilastine was safe, well tolerated, and effective for patients with SAR and PAR. The observed improvement was maintained for the duration of the study, with no loss of drug efficacy (registration number JapicCTI-142622).
What is the side effects of bilastine?
Is bilastine safe for long term?
In conclusion, long-term treatment with bilastine 20 mg once daily for 52 weeks is safe and well tolerated in Japanese patients with CSU or pruritus associated with skin diseases. Bilastine improved disease symptoms of both conditions early in treatment, and the efficacy was maintained throughout the treatment.
What is the oral bioavailability of bilastine?
Absorption is reduced by a high-fat breakfast or fruit juice, and the estimated global oral bioavailability is approximately 60%. Bilastine has linear pharmacokinetics in the 2.5–220 mg dose range in healthy adult subjects without evidence of accumulation after 14 days of treatment.
Is base bilastine a second generation antihistamine?
Bilastine can be therefore classified into the same chemical group as many of the new antihistamines on the market, although it is not structurally derived, nor is it a metabolite or enantiomer of any of them, but an original molecule designed with the intent of fulfilling all the requirements of a second-generation antihistamine.
What is the difference between cetirizine and bilastine?
Remarkably, 20 and 50 mg of bilastine reduced the wheal and flare reaction significantly more quickly than cetirizine. ^ a b “Ilaxten 20 mg tablets – Summary of Product Characteristics (SmPC)”. (emc).
What is the role of bilastine in the treatment of allergic rhinitis?
Additionally, bilastine has been shown to improve quality of life, and all nasal and eye symptoms related to allergic rhinitis. The clinical efficacy of bilastine in allergic rhinitis (AR) and urticaria has been assessed in 10 clinical assays in which over 4,600 patients were involved.