What is the difference between clopidogrel and ticagrelor?

Ticagrelor works more quickly than clopidogrel. Within 30 minutes, a 180mg loading dose of ticagrelor inhibited 41% of platelets. It takes almost 8 hours for clopidogrel 600mg to achieve this same effect. Maximum platelet inhibition (88% inhibition) was reached two hours after a dose of ticagrelor.

Table of Contents

What is the difference between prasugrel and clopidogrel?

Prasugrel is a novel thienopyridine antiplatelet agent recently approved for the treatment of patients with ACS undergoing PCI. Prasugrel provides greater and more consistent platelet inhibition than clopidogrel due to earlier and more extensive formation of its active metabolite.

Can clopidogrel and ticagrelor be taken together?

clopidogrel ticagrelor Using ticagrelor together with clopidogrel may increase the risk of bleeding.

Is ticagrelor an antiplatelet?

Ticagrelor is an antiplatelet medicine. It makes your blood flow through your veins more easily. This means your blood will be less likely to make a dangerous blood clot. Taking ticagrelor can help prevent blood clots if you have an increased risk of having them.

What are the benefits of ticagrelor?

Ticagrelor has more remarkable beneficial outcomes in reversible long-term P2Y12 inhibition than clopidogrel in the total death, cardiovascular prevention, stent thrombosis as well as myocardial infarction without increasing the major bleeding rates in a wide ACS patient population with timely intervention, according …

What is the best alternative to clopidogrel?

Besides oral anticoagulants, such as warfarin and the more recent dabigatran[9], and niche agents, such as cilostazol and ticlopidine[10,11], the most promising alternatives to clopidogrel in those with background aspirin therapy are prasugrel and ticagrelor.

What are the most common side effects of prasugrel?

Common side effects of Prasugrel include:

Bleeding.
Anemia.
Atrial fibrillation.
Back pain.
Slow heart rate.
Dizziness.
Shortness of breath.
Headache.

Is prasugrel better than aspirin?

Results. Of the 56 patients, 24 (43%) were receiving aspirin for primary prevention of ischaemic events and 32 (57%) for secondary prevention. Prasugrel was the strongest inhibitor of ADP-induced PA (mean ± SD maximum response to 20μmol/L ADP 77.6 ± 8.4% [aspirin] vs. 57.7 ± 17.6% [clopidogrel] vs.

What are the benefits of ticagrelor over clopidogrel?

Why is ticagrelor given with aspirin?

The evidence shows that ticagrelor, in combination with aspirin, is effective at reducing the risk of further heart attacks and strokes in people who have already had a heart attack.

Can ticagrelor cause shortness of breath?

Dyspnea is a common side effect of ticagrelor, and can lead to drug discontinuation in roughly 1 in every 20 treated patients. Studies have suggested that ticagrelor inhibits the sodium-independent equilibrative nucleoside transporter–1, which may increase adenosine plasma levels and explain drug-related dyspnea.

Are there any side effects when you stop taking ticagrelor?

If you stop taking the drug suddenly or don’t take it at all: If you stop taking ticagrelor, you’ll have an increased risk of a heart attack, stroke, and death. Your doctor may tell you to stop taking this drug for a short time if you need to have surgery or treat serious bleeding.

Does ticagrelor cause tiredness?

This medicine may cause heart rhythm problems (eg, bradyarrhythmia). Check with your doctor right away if you have chest pain or discomfort, lightheadedness, dizziness, or fainting, trouble breathing, slow or irregular heartbeat, or unusual tiredness.

Can clopidogrel damage kidneys?

Chronic kidney disease is associated with adverse outcomes among elderly patients taking clopidogrel after hospitalization for acute coronary syndrome.

How long can you take prasugrel?

The optimal duration of dual antiplatelet therapy with prasugrel after TAXUS Liberté paclitaxel-eluting stent remains unknown, but appears to be >30 months.

What is the best time of day to take prasugrel?

Prasugrel comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take prasugrel at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

How long can you stay on prasugrel?

It is likely you will require a course of treatment with prasugrel which lasts for up to 12 months. If you buy any medicines, check with a pharmacist that they are suitable for you to take with prasugrel tablets.

How long should prasugrel be taken?

Frequently asked questions about Effient (prasugrel) After getting a stent in the heart, most people need to take Effient (prasugrel) for at least 12 months. Depending on your other medical problems, you may need to take Effient (prasugrel) for a shorter or longer period of time.

Can I take clopidogrel instead of ticagrelor?

Importance Guidelines currently recommend ticagrelor over clopidogrel for patients with acute coronary syndrome (ACS) based on randomized clinical trial data in which ticagrelor reduced major adverse coronary events (MACE) vs clopidogrel but increased bleeding and dyspnea.