What is the antidote for colchicine?
There is no specific antidote for colchicine toxicity; charcoal may be considered, but treatment is supportive.
How is colchicine poisoning treated explain each treatment?
For the treatment of gout, the recommended dose of colchicine is 0.5 to1. 2 mg orally at the onset of symptoms followed by 0.5-0.6 mg every two hours until pain is relieved or nausea, vomiting, or diarrhea develops. Symptoms generally abate within twelve hours and resolve within 48-72 hours.
What happens if you take too much colchicine?
Symptoms of taking too much colchicine can include: feeling or being sick (nausea or vomiting) stomach ache. bloody diarrhoea.
What does colchicine toxicity look like?
Abdominal pain, diarrhoea, nausea and vomiting are usually the first symptoms of colchicine toxicity. A burning sensation in the throat, abdomen or on the skin has also been reported. These symptoms, particularly diarrhoea, can also occur with doses within the therapeutic range.
How much colchicine is an overdose?
Although the lethal dose of colchicine is considered to be 0.8 mg/kg, patient fatalities have been reported from lower doses, following an acute disease course.
How long do side effects of colchicine last?
The majority of side effects from colchicine are considered minor and short-lived. These usually include gastrointestinal side effects like abdominal pain, nausea, vomiting, and diarrhea that can start as early as two hours after initiating treatment. The symptoms may linger for a few days or up to a couple of weeks.
How long does it take for colchicine to leave system?
Due to the high levels of tissue uptake of colchicine, only 10% of a single dose is eliminated in the first 24 hours. Consequently, the elimination of colchicine from the body may continue for 10 days or more after the cessation of treatment.