Can Lasix cause ototoxicity?
Some classes of diuretics, commonly called water pills, have ototoxic properties. These drugs include Lasix (furosemide) and Demadex (torsemide), and can cause ringing in the ears or hearing loss that usually goes away when the medication is discontinued. Aspirin.
How do I monitor ototoxicity?
To detect ototoxicity, it is necessary to monitor a response that is both sensitive to ototoxic damage and reliable over time. Serial audiograms using conven- tional and ultra-high frequency threshold testing, evoked OAEs, and ABR can effectively detect clinically significant changes in auditory function.
How do you manage ototoxicity?
Management options include modification to the medication (drug withdrawal, dosage modification, and alternating with non-ototoxic medications to increase exposure-free durations), supporting the hearing function (prescribing hearing aids or cochlear implants), minimising the disability (assistive listening devices.
What medications can cause ototoxicity?
Other common medications that can cause ototoxicity include the following:
- Certain anticonvulsants.
- Tricyclic antidepressants.
- Anti-anxiety medications.
- Antimalarial medications.
- Blood pressure controlling medications.
- Allergy medications.
- Chemotherapy drugs, including cisplatin.
Is furosemide ototoxicity reversible?
Furosemide ototoxicity—manifested by tinnitus, vertigo, or hearing loss—is frequently reversible, but some cases may result in permanent hearing loss.
How does Lasix cause deafness?
Damage from loop diuretics such as furosemide (Lasix) and bumetanide is caused by changes in the balance of fluids and salts of the inner ear, which can result in tissue swelling and issues with transmission of nerve signals.
What is ototoxicity Slideshare?
Ototoxicity is, quite simply, ear poisoning (oto = ear, toxicity = poisoning), which results from exposure to drugs or chemicals that damage the inner ear or the vestibulo-cochlear nerve (the nerve sending balance and hearing information from the inner ear to the brain). Read more. Health & Medicine.
Is furosemide ototoxic?
Abstract. Furosemide is an ototoxic diuretic. Furosemide injection is followed by a rapid, but reversible decrease of the endocochlear potential and eighth nerve action potential with a more gradual decrease of the endolymph potassium concentration.
Can Lasix cause tinnitus?
Loop Diuretics like Lasix can cause tinnitus, especially at higher doses.
Can furosemide cause deafness?
In small studies, furosemide use has been associated with sudden sensorineural hearing loss that is usually reversible but can be permanent 11–13. The hearing loss is more likely to occur following intravenous drug administration but can also occur after oral dosing 11, 13.
Is hearing loss from Lasix permanent?
In small studies, furosemide use has been associated with hearing loss that is usually reversible, but can be permanent.
Why is furosemide ototoxic?
Loop diuretics like furosemide are known for their effects on the kidneys, where they act on the Na+-K+-2Cl− transporters specifically on the ascending limb of the loop of Henle. This effect is mimicked in the ear and can lead to hearing loss for the duration of treatment.
Why do loop diuretics cause ototoxicity?
The most likely mechanism responsible for the potentiation of ototoxicity by loop diuretics is damage to the tight cell junctions in the blood vessels in the stria vascularis resulting in temporary disruption of the blood-cochlear barrier which increases the permeability of the lateral wall to ototoxic drugs.
Can ototoxicity reversed?
Until a drug is found that can prompt regeneration of stereocilia in adult human ears, there is no cure for hearing loss. However, there are a number of options available to treat it. Many people experiencing hearing loss have found success with hearing devices.
What is ototoxic hearing loss?
Ototoxicity refers to damage to the hearing and / or balance organs that occurs after exposure to medications or chemicals that affect the inner ear. Ototoxic medications can damage hearing, balance, or both.
Which among the following diuretic is ototoxic?
The loop diuretic furosemide is associated with ototoxicity, particularly when doses exceed 240 mg per hour. The related compound ethacrynic acid has a higher association with ototoxicity, and is therefore used only in patients with sulfa allergies.
What do you monitor when taking furosemide?
Careful monitoring of the patient’s clinical condition, daily weight, fluids intake, urine output, electrolytes, i.e., potassium and magnesium, kidney function monitoring with serum creatinine and serum blood urea nitrogen level is vital to monitor the response of furosemide.
Is hearing loss from Lasix reversible?
How does furosemide damage hearing?
Rodent models have shown that furosemide causes dysfunction of the stria vascularis, resulting in reduced endocochlear potential 14–18. Chronically impaired endocochlear potential has been shown to reduce auditory nerve activity, thereby impairing hearing 19.
What is the best technique for ototoxicity monitoring of unresponsive patients?
Three objective evaluation procedures have potential for ototoxicity monitoring of unresponsive patients: otoacoustic emissions (OAE), electrocochleography (ECochG), and auditory brainstem response (ABR). These techniques are in various stages of development for use as objective ototoxicity monitoring tools.
What is the role of the audiologist in the treatment of ototoxic medications?
The interaction between physicians and audiologists is valuable with respect to decision processes that weigh the need for ototoxic medications against the risk of acquired auditory and vestibular pathology. The audiologist is also responsible for implementing appropriate rehabilitation measures as necessary.
What is ototoxic hearing loss and how can it be treated?
If an ototoxic hearing loss results in communication deficit, the audiologist is ethically bound to begin, or recommend, aural rehabilitation (including amplification, assistive listening devices, speechreading, etc.). Intervention should begin as soon as possible after hearing loss has been identified.
How can we detect ototoxic drug toxicity early?
An effective monitoring program should detect ototoxic damage before the patient becomes aware of ototoxic symptoms. Such early detection allows health care providers to consider treatment alternatives such as modifying drug dosage or changing to a less toxic drug to slow or halt the progression of inner ear damage.