How are floating microspheres prepared?
The floating microspheres were prepared by the emulsion solvent diffusion technique. A solution or suspension of Eudragit® S and glipizide with CS in ethanol and dichloromethane was poured into an agitated aqueous solution of polyvinyl alcohol.
What is hollow microspheres?
Hollow microspheres are in strict sense, spherical empty particles without core. These microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers, ideally having a size less than 200 micrometer.
What are microspheres in pharmacy?
Microspheres are polymeric micron range particles with sizes from 1 to 1000 µm (Table 10.1). These microspheres are used for drug delivery, wherein the drug can be encapsulated or entrapped form. Based on the polymeric composition of microspheres, they can be classified into two types: natural and synthetic.
What is microsphere drug delivery?
Controlled drug delivery system (Microspheres) releases the drug in controlled rate and overcome the problems of conventional drug delivery system and enhances the therapeutic efficacy of a given drug 1.
How do microspheres grow?
Upon heating, the outer themoplastic shell softens and the gas inside the shell expands, resulting in a dramatic increase in the volume of the microsphere. The particle size of the microspheres ranges from 10 to 32 μm in their unexpanded form.
What is the difference between microspheres and microcapsules?
– A microcapsule has a liquid core and a solid shell. – A microsphere is a matrix with an active principle dispersed inside. A microcapsule has an inner core & an outer shell. The core can be either liquid (oil or water) or solid and typically contains the active ingredient while the shell is usually a polymer or wax.
Which is the example of natural used in preparation of the microspheres?
| Q. | Which are the examples of natural material used in preparation of the microspheres? |
|---|---|
| B. | Gelatin |
| C. | All |
| D. | None |
| Answer» c. All |
What do you mean by microsphere?
Listen to pronunciation. (MY-kroh-sfeer) A very tiny, hollow, round particle made from glass, ceramic, plastic, or other materials. Microspheres injected into blood vessels that feed a tumor may kill the tumor by blocking its blood supply.
How is a microsphere prepared?
Microspheres were prepared by the emulsion method. Basic materials of microspheres PLA with PCL were dissolved in a volatile organic solvent of dichloromethane then was emulsified, and dispersed in another solvent that do not interfere each other to form microparticles called microspheres.
Why is microsphere prepared?
Microspheres are a novel drug delivery approach to control release of pharmacologically active ingredient as per patient needs. Natural polymers are cheap, biodegradable and have been proved safe for pharmaceutical formulation.
What are floating microspheres?
Floating microspheres are, in a strict sense, spherical empty particles without a core. These are free- owing particles, with size ranging from 1 to 1000 µm. solvent evaporation method. This gastrointestinal transit- with a specific density of less than one.
Why floating microsphere is the best drug delivery system?
The most comfortable and choicely drug delivery system is microsphere and floating microsphere is one of the best microspheres which bring a revolution in novel drug delivery system. Hypertension is a long-term increase in blood pressure that causes end-organ damage as well as increased morbidity and death.
What are the advantages of floating microspheres in gastric implants?
These floating microspheres have the advantage that they remain buoyant and distributed uniformly over the gastric fluid to avoid the vagaries of gastric emptying and release the drug for prolonged period of time.
How are the microspheres spread over the surface?
The microspheres are spread over the surface a paddle rotated at 100 rpm. Disintegration test solution used as a dispersing medium to simulate gastric uid. After ered separately. After drying, each fraction of the hollow