What are DNA binding sites for proteins?
DNA binding sites can be thus defined as short DNA sequences (typically 4 to 30 base pairs long, but up to 200 bp for recombination sites) that are specifically bound by one or more DNA-binding proteins or protein complexes.
What is the binding site for transcription factor ap1?
The AP-1 binding site was identified as the 12-O-Tetradecanoylphorbol-13-acetate (TPA) response element (TRE) with the consensus sequence 5′-TGA G/C TCA-3′.
How many binding sites are there?
As a result of our similarity search, 38 similar binding sites were found, and they could be classified into seven putative binding sites according to their position on the query protein (Table 1).
What does ETS transcription factor do?
Function. The ETS family is present throughout the body and is involved in a wide variety of functions including the regulation of cellular differentiation, cell cycle control, cell migration, cell proliferation, apoptosis (programmed cell death) and angiogenesis.
Where is protein binding site?
A binding site is a position on a protein that binds to an incoming molecule that is smaller in size comparatively, called ligand. In proteins, binding sites are small pockets on the tertiary structure where ligands bind to it using weak forces (non-covalent bonding).
What is the function of TATA-binding protein?
TATA-binding protein works as part of a larger transcription factor, TFIID, that starts the process of transcription. After it binds to the promoter, it recruits additional transcription factors.
Is ETS an oncogene?
The ETS portion of the oncogene is essential for erythroblastosis in infected chickens3 and affects myeloid transformation4. Hence, the name ETS is derived from E-twenty-six-specific sequence, or E26 transforming sequence.
What is C-fos and c jun?
The c-jun and c-fos proto-oncogenes encode proteins that form a complex which regulates transcription from promoters containing AP-1 activation elements. c-Jun has specific DNA binding activity, while c-Fos has homology to the putative DNA binding domain of c-Jun.
Where can I find TFAP2A human gene details?
TFAP2A human gene details in the UCSC Genome Browser. This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Does the risk allele disrupt a binding site for AP-2 alpha?
Analysis of transcription factor binding site analysis showed that the risk allele disrupt a binding site for AP-2 alpha.
What is the AP-2 gene Alternative splicing?
“An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2”. Molecular and Cellular Biology. 13 (7): 4174–85. doi: 10.1128/mcb.13.7.4174. PMC 359967. PMID 8321221. Williamson JA, Bosher JM, Skinner A, Sheer D, Williams T, Hurst HC (Jul 1996).