Disorders of primary hemostasis
What are the main disorders of hemostasis?
Disorders of primary hemostasis
- Platelet deficiency (see “Etiology” in “Thrombocytopenia”)
- Platelet dysfunction (thrombocytopathy): disorders that lead to dysfunctional adhesion or aggregation of platelets. Inherited. Von Willebrand disease. Bernard-Soulier syndrome. Glanzmann thrombasthenia. Acquired.
What are the two major types of hemostasis disorders?
There are two types: Type A, which is a deficiency in factor VIII, and Type B, also known as Christmas disease, which is a deficiency in factor IX.
What are the different types of bleeding disorders?
There are many different types of bleeding disorders, hemophilia A (factor VIII deficiency), hemophilia B (factor IX deficiency), von Willebrand disease, and rare factor deficiencies including I, II, V, VII, X, XI, XII and XIII.
What causes hemostatic disorders?
Bleeding disorders such as hemophilia and von Willebrand disease result when the blood lacks certain clotting factors. These diseases are almost always inherited, although in rare cases they can develop later in life if the body forms antibodies that fight against the blood’s natural clotting factors.
What are the possible causes of bleeding disorders?
Some bleeding disorders, such as hemophilia, can be inherited or acquired. Others can occur from such conditions as anemia, cirrhosis of the liver, HIV, leukemia, and vitamin K deficiency. They also can result from certain medications that thin the blood, including aspirin, heparin, and warfarin.
What is the most common cause of bleeding disorders?
Platelet disorders are the most common cause of bleeding disorder and are usually acquired rather than inherited.
What are the three parts of hemostasis?
Hemostasis involves three basic steps: vascular spasm, the formation of a platelet plug, and coagulation, in which clotting factors promote the formation of a fibrin clot.
What is a hematological disorder?
Hematologic disorders involve the blood and include problems with red blood cells, white blood cells, platelets, bone marrow, lymph nodes, and spleen. Children can experience a variety of disorders, some are genetic while others are acquired.
What is hemostasis?
Hemostasis is your body’s natural reaction to an injury that stops bleeding and repairs the damage. This capability is usually for your benefit, conserving blood and preventing infections.
What is the cause of hemostasis?
Hemostasis occurs when blood is present outside of the body or blood vessels. It is the innate response for the body to stop bleeding and loss of blood. During hemostasis three steps occur in a rapid sequence. Vascular spasm is the first response as the blood vessels constrict to allow less blood to be lost.
What is the importance of hemostasis?
Hemostasis is your body’s normal reaction to an injury that causes bleeding. This reaction stops bleeding and allows your body to start repairs on the injury. This capability is essential to keep you alive, particularly with significant injuries.
What causes hematological diseases?
Many blood diseases and disorders are caused by genes. Other causes include other diseases, side effects of medicines, and a lack of certain nutrients in your diet. Common blood disorders include anemia and bleeding disorders such as hemophilia.
What are hemostasis disorders?
Hemostasis Disorders Hemostasis The process of blood clotting and then the subsequent dissolution of the clot, following repair of the injured tissue, is termed hemostasis.
What are the major events of hemostasis?
Hemostasis – major events 1. Vascular constriction. 2. Platelets become activated by thrombin and aggregate at the site of injury, forming a temporary, loose platelet plug. 3. To insure stability of the initially loose platelet plug, a fibrin mesh (also called the clot) forms and entraps the plug.
What are the hematologic disorders causing bleeding?
Hematologic disorders causing bleeding • Vascular disorders – Scurvy, easy bruising, • Platelet disorders – Low Number or abnormal function • Coagulation disorders – Factor deficiency. • Mixed/Consumption – DIC
What are the three stages of blood coagulation?
Blood Coagulation • coagulation of blood occurs due to activation of clotting factors • occurs in three major stages: • Formation of prothrombin activator • Extrinsic pathway • Intrinsic pathway • Conversion of prothrombin to thrombin • Conversion of fibrinogen to fibrin 8.