What is beta-catenin positive?
In summary, high-level nuclear β-catenin staining may be useful as a diagnostic marker for desmoid-type fibromatosis, as only a very limited subset (solitary fibrous tumor, synovial sarcoma, and endometrial stromal sarcoma) of other mesenchymal neoplasms are positive for this marker.
What is beta-catenin?
In the canonical Wnt cascade, β-catenin is the key effector responsible for transduction of the signal to the nucleus and it triggers transcription of Wnt-specific genes responsible for the control of cell fate decisions in many cells and tissues.
Is beta-catenin an enzyme?
Catenin beta-1, also known as beta-catenin (β-catenin), is a protein that in humans is encoded by the CTNNB1 gene. Chr. Chr. Beta-catenin is a dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription.
Is beta-catenin good?
β-catenin is an intracellular molecule involved in cell adhesion, cell signaling, and regulation of gene transcription. It plays essential roles in kidney development and in the pathogenesis of renal dysplasia.
How do I activate catenin beta?
The Wnt/β-catenin pathway is activated when a Wnt ligand binds to a seven-pass transmembrane Frizzled (Fz) receptor and its co-receptor, low-density lipoprotein receptor related protein 6 (LRP6) or its close relative LRP5.
How is beta-catenin regulated?
β-Catenin is a pivotal component of the Wnt signaling pathway and it is tightly regulated at three hierarchical levels: protein stability, subcellular localization and transcriptional activity.
Is beta-catenin a tumor suppressor gene?
In colon and other cancers, mutations in the APC tumor suppressor protein or beta-catenin’s amino terminus stabilize beta-catenin, enhancing its ability to activate transcription of Tcf/Lef target genes.
How is beta catenin degraded?
Ubiquitinated β-catenin is degraded by the proteasome. The molecular mechanisms that underlie several aspects of destruction complex function are poorly understood, particularly the role of APC.
What is beta beta catenin made of?
beta-catenin is a 92-kDa protein that binds to the cytoplasmic tail of E-cadherin. It acts in the nucleus to stimulate cell proliferation and is degraded by complexing with the adenomatous polyposis coli gene.
Where does β catenin go after Wnt activation?
Upon Wnt activation, β catenin is translocated from membrane (where it interacts with E-cadherin) to cytoplasm and nucleus, where it interacts with transcriptional activators Interpretation: nuclear staining is significant in fibroblasts; nuclear or cytoplasmic staining is significant in epithelial cells
What is beta-catenin immunohistochemistry used for?
Immunohistochemistry for beta-catenin may be useful in the differential diagnosis of selected tumors of soft tissue, the gastrointestinal tract, including the pancreas, lung, and female genital tract. Biomarkers, Tumor* / analysis Humans