What is the ligand for LFA-1?
LFA-1 has three main ligands: ICAM-1 and -2 (CD102) on vascular endothelial cells and leukocytes, and ICAM-3 (CD50) only on leukocytes (De Fougerolles et al., 1994).
What does VCAM stand for?
Vascular cell adhesion molecule
Vascular cell adhesion molecule (VCAM-1) is a cytokine-inducible surface molecule that mediates adhesion of various leukocyte types, such as lymphocytes, monocytes, and eosinophils.
Is ICAM-1 a glycoprotein?
ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system.
What is ICAM security?
Identity, credential, and access management (ICAM) comprises the tools, policies and systems that allow an organization to manage, monitor and secure access to protected resources.
What does VLA 4 do?
The integrin VLA-4 is expressed on the cell surfaces of stem cells, progenitor cells, T and B cells, monocytes, natural killer cells, eosinophils, but not neutrophils. It functions to promote an inflammatory response by the immune system by assisting in the movement of leukocytes to tissue that requires inflammation.
Is selectin and integrin?
In brief, selectin-selectin ligand interactions lead to rolling of the leukocyte on endothelial cells, allowing activation of the cell by chemokines present on the endothelium. This leads to activation of integrins on the surface of the immune cell (15).
What is ICAM and VCAM?
Intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) are endothelial CAMs of the immunoglobulin (Ig) superfamily with a critical role in mediating the firm adhesion of leukocytes to endothelial cells in various acute and chronic inflammatory diseases.
Is VCAM 1 an integrin?
VCAM-1 and α4β1 integrin play a central role in leukocyte recruitment during inflammation.
What is the function of ICAM 1 and VCAM-1 in inflammation?
What is DISA ICAM?
The DISA ICAM solution will secure identity, access, and account management for Defense Department (DoD) applications. The contract is worth up to $162 million with a one-year base period and four option years.
How do I set up ICAM?
Video: Simple remote video surveillance
- Step 1: Set up iCam on your computer(s) Head to http://skjm.com/icam/support.php and download iCamSource for Mac or PC.
- Step 2: Install iCam on your Android or iOS device. With your cameras set up, you’re ready to start remotely viewing the surveillance with your mobile device.
What does ICAM-1 bind to?
ICAM-1 possesses binding sites for a number of immune-associated ligands. Notably, ICAM-1 binds to macrophage adhesion ligand-1 (Mac-1; ITGB2 / ITGAM ), l eukocyte f unction associated antigen-1 ( LFA-1 ), and fibrinogen.
Is ICAM-1 a biosensor?
Importantly, ICAM-1 serves as a biosensor to transduce outside-in-signaling via association of its cytoplasmic domain with the actin cytoskeleton following ligand engagement of the extracellular domain.
What is intercellular adhesion molecule-1 (ICAM-1) expression in oral cancer?
Usami Y, Ishida K, Sato S, et al. Intercellular adhesion molecule-1 (ICAM-1) expression correlates with oral cancer progression and induces macrophage/cancer cell adhesion. Int J Cancer. 2013;133:568–578.
What is the role of ICAM-2 in leukocyte adhesion and integrin affinity?
^ Kotovuori A, Pessa-Morikawa T, Kotovuori P, Nortamo P, Gahmberg CG (Jun 1999). “ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity”. Journal of Immunology. 162 (11): 6613–20. PMID 10352278.