What drug classification is baclofen?
Baclofen is in a class of medications called skeletal muscle relaxants. Baclofen acts on the spinal cord nerves and decreases the number and severity of muscle spasms caused by multiple sclerosis or spinal cord conditions. It also relieves pain and improves muscle movement.
What is the chemical name for baclofen?
Baclofen hydrochloride
| PubChem CID | 6602720 |
|---|---|
| Molecular Formula | C10H13Cl2NO2 |
| Synonyms | Baclofen hydrochloride 28311-31-1 4-amino-3-(4-chlorophenyl)butanoic acid hydrochloride STX 209 hydrochloride 4-amino-3-(4-chlorophenyl)butanoic acid;hydrochloride More… |
| Molecular Weight | 250.12 |
| Parent Compound | CID 2284 (Baclofen) |
Is baclofen a benzodiazepine?
Baclofen and Valium belong to different drug classes. Baclofen is a muscle relaxant and antispastic and Valium is a benzodiazepine. Side effects of baclofen and Valium that are similar include drowsiness, weakness, dizziness, tiredness, nausea, and constipation.
Is baclofen an Nsaid drug?
No. Baclofen is a muscle relaxer. While it can relieve pain due to muscle spasms, it does not relieve pain due to other types of pain such as inflammatory or nerve pain.
Is baclofen an anticholinergic?
Systematic review of anticholinergic risk scales in older adults….
| Class | Drugs | Relative anticholinergic potency |
|---|---|---|
| Muscle relaxant | Orphenadrine, tizanidine | High |
| Cyclobenzaprine*, baclofen, methocarbamol | Low |
Is baclofen an alpha blocker?
Similarly to phenibut (β-phenyl-GABA), as well as pregabalin (β-isobutyl-GABA), which are close analogues of baclofen, baclofen (β-(4-chlorophenyl)-GABA) has been found to block α2δ subunit-containing voltage-gated calcium channels (VGCCs).
Is baclofen a GABA agonist?
Baclofen (β-[4-chlorophenyl] GABA) is a stereospecifically active agonist at the GABAB receptor (Bowery et al., 1981). It has been used therapeutically as a muscle relaxant and for the treatment of trigeminal neuralgia (Korolkovas, 1999).
Is baclofen Lorazepam?
Are Ativan and Baclofen the Same Thing? Baclofen and Ativan (lorazepam) are muscle relaxants used for treating spasm of skeletal muscles. A difference is baclofen is also used to treat muscle clonus, rigidity, and pain caused by multiple sclerosis.
Is baclofen an antidepressant?
Pre-clinical studies also found that baclofen can produce the characteristic behavioural effects usually observed with other antidepressant drugs. Indeed, baclofen (0.25 mg/kg) decreased immobility time in animals during the forced swimming test (FST), which is considered to reflect antidepressant properties [11].
Is baclofen an anticonvulsant?
Abstract. Baclofen has been reported to be epileptogenic in man, but many animal studies have demonstrated an anticonvulsant effect. In 12 patients with a history of epilepsy, baclofen was given in the conventional dosage range.
Is baclofen a GABA?
Baclofen is a gamma-aminobutyric acid (GABA) analog that activates the GABA-B receptor subtype, and is used worldwide in neurology for the treatment of spasticity due to its myorelaxant properties (1).
Is baclofen a GABA B agonist?
Is baclofen a dopamine agonist?
Furthermore, preclinical studies have shown that baclofen inhibits dopamine transmission (43–48). Such dopamine antagonist properties do not a priori posit baclofen as a good candidate for the treatment of subjects who have a dopamine-impoverished brain.
What drugs are GABA agonists?
GABA Agonists
| Drug | Drug Description |
|---|---|
| Baclofen | A GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients. |
| Zolpidem | A sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency. |
| Progabide | Indicated for the treatment of epilepsy. |
Does baclofen increase serotonin?
Hyperactivity of serotonin raphe neurons or hyperactivity of the amygdala are mechanisms known to produce anxiety; baclofen acutely inhibits serotonin neurons and serotonin release (27, 28) while short-term baclofen treatment inhibits amygdala reactivity to incentive cues (29).
What is the mechanism of action of baclofen?
Mechanism of Action [3] The thinking is that baclofen reduces the release of excitatory neurotransmitters in the pre-synaptic neurons and stimulates inhibitory neuronal signals in the post-synaptic neurons with resultant relief of spasticity.
What is the drug class of baclofen?
Methocarbamol.
What drug class is baclofen?
Side Effects
Is baclofen a strong drug?
Tizanidine and baclofen are similar drugs that are used to treat muscle spasms that come as a result of nerve damage. Though the drugs are similar, they do have a few differences that are worth noting. The two drugs have slightly different strength levels, which may be an important factor in which one your doctor may direct you towards.
What are the long term side effects of taking baclofen?
Abdominal or stomach pain or discomfort