What is fenfluramine hydrochloride used for?
Pondimin (fenfluramine hydrochloride) is an anorectic drug used to manage exogenous obesity as a short-term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. The brand name Pondimin is discontinued in the U.S., but generic versions may be available.
Is fenfluramine a stimulant?
Fenfluramine is an amphetamine derivative and a sympathomimetic stimulant with appetite-suppressant property. Fenfluramine, which was part of the Fen-Phen anti-obesity medication, stimulates the release of serotonin from vesicular storage, and modulates serotonin transporter function.
Is fenfluramine an antidepressant?
Fenfluramine is a selective serotonin reuptake inhibitor (SSRI), which increases serotonin content in the brain’s synapses to decrease caloric intake. Anorexia and weight loss induced by fenfluramine have been demonstrated in numerous early therapeutic trials .
Is fenfluramine available in the US?
About FINTEPLA® (fenfluramine) C-IV In the United States, FINTEPLA is available only through a restricted distribution program called the FINTEPLA REMS program.
Is fenfluramine a controlled substance?
SUPPLEMENTARY INFORMATION: In 1973, fenfluramine, its salts, isomers and salts of isomers were placed into schedule IV of the Controlled Substances Act (CSA), 21 CFR 1308.14(d).
What is the generic fenfluramine?
Fenfluramine is the generic name (non-brand name) of a seizure medicine with the brand name Fintepla® from Zogenix.
What is the meaning of fenfluramine?
Definition of fenfluramine : an anorectic amphetamine derivative C12H16F3N with little stimulant effect on the central nervous system formerly used in the form of its hydrochloride to treat obesity but no longer used due to its association with heart valve disease — see fen-phen sense 1.
Where can I get fenfluramine?
Because of the risks with this medication, fenfluramine is available only through a special restricted distribution program. A program called Fintepla Risk Evaluation and Mitigation Strategies (REMS) program. You, your doctor, and your pharmacy must be enrolled in the Fintepla REMS program before you can receive it.
Is fenfluramine still available?
Fenfluramine was withdrawn from the U.S. market in 1997 after reports of heart valve disease and continued findings of pulmonary hypertension, including a condition known as cardiac fibrosis.
Why was fen-phen taken off the market?
The FDA ordered fenfluramine and dexfenfluramine off the market in September 1997 after those drugs were linked to heart valve problems. Fenfluramine was one of the ingredients in “fen-phen,” and dexfenfluramine is closely related to fenfluramine.
Is fenfluramine available in Canada?
The PReSS team helps HHS patients gain access to medications unavailable in Canada through its Special Access Program. Fenfluramine, the medication the girls have been on for just over six months, isn’t marketed in Canada.
Can you buy fenfluramine?
Why was fenfluramine taken off the market?
What is ephedrine prescribed for?
Ephedrine is a prescription medicine used to treat the symptoms of low blood pressure during anesthesia (Hypotension). Ephedrine may be used alone or with other medications. Ephedrine belongs to a class of drugs called Alpha/Beta Adrenergic Agonists.
Is ephedrine a painkiller?
Ephedrine is a medication and stimulant. It is often used to prevent low blood pressure during anesthesia. It has also been used for asthma, narcolepsy, and obesity but is not the preferred treatment….Ephedrine.
|Duration of action||IV/IM (60 min), by mouth (2 h to 4 h)|
|Excretion||22% to 99% (urine)|
What is fenfluramine used for?
Fenfluramine acts primarily as a serotonin releasing agent. It increases the level of serotonin, a neurotransmitter that regulates mood, appetite and other functions.
What are the side effects of fenfluramine?
Heart valve disease. Since fenfluramine and its active metabolite norfenfluramine stimulate serotonin receptors, this may have led to the valvular abnormalities found in patients using fenfluramine. In particular norfenfluramine is a potent inhibitor of the re-uptake of 5-HT into nerve terminals.
Can fenfluramine hydrochloride be used to treat seizures in Dravet syndrome?
Zogenix. Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial Lancet.
Why is fenfluramine only available under a restricted program?
Because of the risks of pulmonary arterial hypertension, fenfluramine is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the FINTEPLA REMS.