Is OEA an endocannabinoid?
OEA is a shorter, monounsaturated analogue of the endocannabinoid anandamide, but unlike anandamide it acts independently of the cannabinoid pathway, regulating PPAR-α activity to stimulate lipolysis.
What is OEA in the body?
Oleoylethanolamide (OEA) is a molecule produced in the body, usually found in the intestines. It is responsible for the feeling of satiety after meals. Further research is needed to determine if oral supplementation of OEA provides benefits for weight loss.
What is OEA weight loss?
Oleoylethanolamide (OEA) is an endocannabinoid-like lipid that induces hypophagia and reduces fat mass in rodents. For over a decade, PPAR-α has been the most widely accepted mediator of the hypophagic action of OEA via signaling to homeostatic brain centers.
How does OEA administered in the gut affect dopamine release in the brain?
When OEA is administered to mice consuming a high-fat diet, dopamine levels increase and abnormalities in brain reward pathways improve. Imbalances in the brain satiety signals contribute to the insatiable intake of large quantities of high-calorie food, which in turn perpetuates weight gain and obesity.
How do cannabinoids relieve pain?
The mechanisms of the analgesic effect of cannabinoids include inhibition of the release of neurotransmitters and neuropeptides from presynaptic nerve endings, modulation of postsynaptic neuron excitability, activation of descending inhibitory pain pathways, and reduction of neural inflammation.
Where is Oleoylethanolamide from?
The lipid sensor oleoylethanolamide (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor-α (PPAR-α) secreted in the proximal intestine, is endowed with several distinctive homeostatic properties, such as control of appetite, anti-inflammatory activity, stimulation of lipolysis and …
Can gut bacteria cause mental illness?
Increasing evidence has associated gut microbiota to both gastrointestinal and extragastrointestinal diseases. Dysbiosis and inflammation of the gut have been linked to causing several mental illnesses including anxiety and depression, which are prevalent in society today.
Is CBD a pain killer?
Studies have found CBD, often alongside THC, to be an effective pain reliever for various chronic conditions. In clinical trials, Sativex, a spray with equal parts CBD and THC, proved significantly successful as an analgesic for cancer-related pain.
What is the best CBD strain for pain?
Harlequin. Perhaps the most popular high-CBD strain in North America, Harlequin treats anxiety, chronic pain, inflammation, PMS and cramps, among others. It’s often described as bringing clear-headed and uplifting effects.