What is biphasic synovial sarcoma?
Histologically synovial sarcoma is composed of two morphologically different types of cells that form a characteristic biphasic pattern: epithelial cells resembling those of carcinoma and fibrosarcoma-like spindle cells. There are transitions between epithelial and spindle cells suggesting a close generic relationship.
How is spindle cell sarcoma diagnosed?
Spindle cell sarcoma can affect any age group, but is most common in people over the age of 40. It affects slightly more men than women. We will confirm your diagnosis once we have carried out X-rays, ultrasound and MRI scans (imaging) and have the histology (results) from the biopsy taken from the tumour.
Can MRI detect sarcoma?
MRI (magnetic resonance imaging) MRI scans are often part of the work-up of any tumor that could be a sarcoma. They’re often better than CT scans in evaluating sarcomas in the arms or legs. MRI provides a good picture of the extent of the tumor.
What is a biphasic tumor?
Abstract. A biphasic tumour is a truly histological term that refers to neoplastic tissue which is characterized by two different cellular elements. Several histogenetic theories have been proposed for the aetiogenesis of the biphasic tumours.
Can MRI diagnose sarcoma?
What do spindle cells indicate?
10.69. Spindle cell carcinoma represents a rare variant of squamous cell carcinoma, characterized by spindled tumor cells that simulate a sarcoma but are epithelial in nature. The tumor can arise anywhere within the upper aerodigestive tract, with a predilection for the larynx and oral cavity.
Should you biopsy a sarcoma?
Biopsy. If a soft tissue sarcoma is suspected based on exams and imaging tests, a biopsy is needed to know for sure that it’s a sarcoma and not another type of cancer or a benign (not cancer) disease.
Can sarcoma be seen on CT scan?
CT scan: CT scans are useful when making the initial soft tissue sarcoma diagnosis, and to see if the cancer has spread to other areas of the body. CT scans also may be used to guide a biopsy needle. MRI: An MRI may help outline a tumor in the soft tissues, and may also help determine if cancer cells have spread.
How do you biopsy a sarcoma?
Core needle biopsy for soft tissue sarcoma. A core needle biopsy is a procedure where a doctor takes a sample from a suspicious lump or area of tissue. A specialist (pathologist) looks at the cells under a microscope. A core biopsy helps your doctor decide if it is soft tissue sarcoma.
What is biphasic cell?
Biphasic is the second most common mesothelioma cell type. Epithelial mesothelioma, also known as epithelioid, is the most common and the easiest to treat. The sarcomatoid cell type accounts for 10% to 20% of cases and is more resistant to treatment.
Can a blood test detect sarcoma?
In addition to a physical examination, the following tests may be used to diagnose or determine the stage (or extent) of a bone sarcoma: Blood tests. Sarcomas are never diagnosed by a laboratory blood test.
What is the difference between biphasic synovial and monophasic sarcoma?
In the monophasic variant, the tissue is comprised entirely of spindle-cells whereas in biphasic synovial sarcoma, there are epithelial and spindle-cell components present [7]. In one third of synovial sarcomas, areas of calcifications and/or ossification can be found.
Which immunohistochemical markers are used to diagnose synovial sarcoma?
33 Terry J, Saito T, Subramanian S, et al. TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies. Am J Surg Pathol 2007; 31:240-6Images. Study using tissue microarray.
Which imaging studies are used to diagnose synovial sarcoma?
Similar to other STS, magnetic resonance imaging (MRI) with and without contrast is the gold standard for diagnostic imaging for synovial sarcoma (Figure 2) [17].
Does a synovial sarcoma-specific preoperative nomogram support ifosfamide-based chemotherapy?
A synovial sarcoma-specific preoperative nomogram supports a survival benefit to ifosfamide-based chemotherapy and improves risk stratification for patients. Clin. Cancer Res. 2008;14:8191–8197. doi: 10.1158/1078-0432.CCR-08-0843. [PMC free article][PubMed] [CrossRef] [Google Scholar] 56.