What is Pseudoternary phase diagram?
A pseudoternary phase diagram is a tool that optimizes the three components of any typical emulsion, i.e., water, oil, and surfactant, to obtain the concentration range of these components, which form a stable emulsion. The three components of a system are plotted on the three corners of the triangle.
How do you read a pseudo ternary phase diagram?
Reading Ternary Diagrams
- Locate the 1 (or 100%) point on the axis.
- Draw a line parallel to the base that is opposite the 100% point through the point you wish to read.
- Follow the parallel line to the axis.
- Repeat these steps for the remaining axes.
What is term micro emulsion?
Definition of microemulsion : an emulsion in which the dispersed phase is in the form of very small droplets usually produced and maintained with the aid of surfactants and having diameters of from 50 to 500 angstroms.
What is tri phase diagram?
A Ternary Phase Diagram shows the phases of a three component system. Normally, we represent these phases in a triangular diagram where the apices of the triangle represent the three pure components and the distance from an apex is a measure of it’s concentration.
What is microemulsion used for?
Microemulsions have ultralow interfacial tension between the water phase and the oil phase. Water-in-oil microemulsions have been used to deliver water-soluble oilfield chemicals into subterranean rock formations.
Why do we use ternary phase diagrams?
A ternary phase diagram shows possible phases and their equilibrium according to the composition of a mixture of three components at constant temperature and pressure.
What are advantages of micro emulsion?
Microemulsions have been proposed as drug delivery systems to enhance the absorption of drug across biological membranes (Majuru and Oyewumi, 2009). Some of microemulsions advantages include: (1) increased solubility and stability of drugs, and (2) ease and economical scale-up.
What is the size of microemulsion?
Microemulsions are transperent systems and typically consist of oil, surfactant, cosurfactant and aqueous phase. They are also thermodynamically stable and has a droplet size <0.15 nm and does not have the tendency to coalesce[5,6].
What is pseudoternary phase diagram construction?
Construction of pseudoternary phase diagram is a critical step in the development of such lipid-based formulation. This system will self-disperse itself as a thermodynamically stable nano drug carrier within the gastrointestinal (GI) lumen [12].
Why pseudoternary phase diagram for hydrophobic drug formulation?
This formulation was designed in order to improve the oral efficacy of hydrophobic drug, which display dissolution rate limited absorption. Construction of pseudoternary phase diagram is an important tool for screening of self-dispersible formulation components and to assess the effect of different component on in-vitro performance of formulation.
What does the nitrogen phase diagram show?
The nitrogen phase diagram shows the phase behavior with changes in temperature and pressure. The curve between the critical point and the triple point shows the nitrogen boiling point with changes in pressure. It also shows the saturation pressure with changes in temperature.
What is the constant ratio in a Pseudo ternary phase diagram?
In the pseudo ternary phase diagram, among the four components, the constant ratio of the two parts is used with the different ratios of the remaining two components [37].