What is the antibacterial spectrum of imipenem?
Imipenem has the widest spectrum of antimicrobial activity of currently available beta-lactam agents and, in contrast to other beta-lactam antibiotics, lacks cross resistance with recently introduced extended-spectrum penicillins and third-generation cephalosporins.
What spectrum is metronidazole?
The nitroimidazole antibiotic metronidazole has a limited spectrum of activity that encompasses various protozoans and most Gram-negative and Gram-positive anaerobic bacteria.
Is imipenem cilastatin broad spectrum?
Imipenem, a broad-spectrum antibiotic, is combined with cilastatin to prevent renal damage by dehydropeptidase.
What class of antibiotics is imipenem?
Imipenem is in a class of medications called carbapenem antibiotics. It works by killing bacteria. Cilastatin is in a class of medications called dehydropeptidase inhibitors.
Is metronidazole considered a broad-spectrum antimicrobial agent?
Outline dosing of metronidazole for some of the more common indications. Describe the importance of antibiotic stewardship when initiating a broad-spectrum antimicrobial like metronidazole.
Which class of antibiotics is metronidazole?
Metronidazole is in a class of medications called nitroimidazole antimicrobials. It works by stopping the growth of bacteria. Antibiotics will not work for colds, flu, or other viral infections.
Is imipenem bactericidal or bacteriostatic?
Imipenem is bactericidal (minimal bactericidal concentrations (MBCs] less than twice the MICs). For P. aeruginosa, MBCs of imipenem are less influenced by high inoculum density rather than are MBCs of antipseudomonal penicillins and cephalosporins.
Is metronidazole broad or narrow spectrum?
Flagyl , known as metronidazole or by the brand name Protostat, is an antibacterial drug that is classified as a broad-spectrum antibiotic. 1 Metronidazole is used to treat certain bacterial infections or protozoal infections (a type of parasite).
Is metronidazole an antimicrobial?
Metronidazole is one of the mainstay drugs for the treatment of anaerobic infections [1,2]. It is approved by the US Food and Drug Administration for the treatment of anaerobic and protozoal infections. Metronidazole exerts its antimicrobial effects through the production of free radicals that are toxic to the microbe.
Is metronidazole bacteriostatic or bactericidal?
Metronidazole is a bactericidal antibiotic. Technically, “antibiotic” refers only to antimicrobials derived from bacteria or molds but is often (including… read more . It enters bacterial cell walls and disrupts DNA and inhibits DNA synthesis in certain microorganisms.
Which antibiotics are narrow spectrum?
Narrow spectrum antibiotics are used for the specific infection when the causative organism is known….Drug names:
- Azithromycin.
- Clarithromycin.
- Erythromycin.
- Clindamycin.
Which antibiotic is broad-spectrum?
Examples of broad-spectrum antibiotics Doxycycline. Minocycline. Aminoglycosides (except for streptomycin) Ampicillin.
Which class of antibiotic is metronidazole?
What type of drug is imipenem?
Imipenem is a β-lactam antibacterial classified as a carbapenem that has the widest activity of all individual antibacterial drugs.
How common are imipenem and meropenem resistance in Enterobacter fragilis?
A study conducted in Taiwan, over a period of 16 years, reported imipenem and meropenem resistance in 7 and 12% of B. fragilis isolates, 4 and 8% of Fusobacterium species and 15 and 0% of Clostridium respectively [ 23 ].
Is imipenem Gram positive or negative?
Imipenem has an unusually broad spectrum, high potency, and no cross-resistance with other beta-lactam antibiotics. Susceptible gram-negative species include Pseudomonas aeruginosa, Serratia, and Enterobacter.
Is imipenem absorbed by the oral route?
Absorption and distribution. Imipenem is not absorbed by the oral route. No accumulation of imipenem is reported following multiple dosing with cilastatin. Imipenem and cilastatin are both widely distributed in multiple fluids and tissues.