What are Coriell samples?
The samples include no identifying or phenotypic information, and are high-quality resources for the study of genetic variation in a range of human populations.
What is Cell Repository?
Cryogenic tanks filled with liquid nitrogen and millions of vials of frozen cells. Credit: Coriell Institute for Medical Research. The NIGMS Human Genetic Cell Repository is a collection of well-characterized, high-quality human cells for use in biomedical research.
What are LCL cells?
Abstract: Lymphoblastoid cell lines (LCLs) represent a convenient research tool for expanding the amount of biologic material available from an individual. LCLs are commonly used as reference materials, most notably from the Genome in a Bottle Consortium.
What is NA12878?
In 2015, NIST released the pilot genome Reference Material 8398, which is genomic DNA (NA12878) derived from a large batch of the Coriell cell line GM12878, characterized for high-confidence SNPs, indel, and homozygous reference regions (Zook, et al., Nature Biotechnology 2014 and Zook, et al., Nature Biotechnology …
What is MCB in cell culture?
Master Cell Bank (MCB) An MCB is defined as an aliquot of a single pool of cells that generally has been prepared from the selected cell clone under defined conditions, dispensed into multiple containers, and stored under defined conditions. The MCB is used to derive all working cell banks (WCB).
What is cell bank in pharma?
A cell bank is a facility that stores cells of specific genome for the purpose of future use in a product or medicinal needs. They often contain expansive amounts of base cell material that can be utilized for various projects.
What is DeepVariant?
DeepVariant is an analysis pipeline that uses a deep neural network to call genetic variants from next-generation DNA sequencing data. This tutorial explains how to run DeepVariant on Google Cloud using sample data. You run DeepVariant on a single Compute Engine instance.
What is HapMap project?
International HapMap Project, an international collaboration aimed at the identification of genetic variations contributing to human disease through the development of a haplotype (haploid genotype) map of the human genome.
What is WCB and MCB?
An MCB is defined as an aliquot of a single pool of cells that generally has been prepared from the selected cell clone under defined conditions, dispensed into multiple containers, and stored under defined conditions. The MCB is used to derive all working cell banks (WCB).
What is the difference between MCB and WCB?
A MCB typically originates from a research cell bank that is the “end point” of cell-line development. A WCB is prepared from a homogenous cell suspension obtained from culturing the MCB under defined culture conditions.
What is MCB and WCB?
What is MCB cell bank?
Research Cell Bank or “RCB” shall mean a small cell bank produced under research conditions used for the production of Research DNA only. This material is provided “as-is”.
What are helper 2 cells?
What are Th2 cells? As their name suggests, T helper (Th) cells provide helper functions to other cells of the immune system—especially the antigen-presenting cells (APCs) such as macrophages, dendritic cells, and B cells—and are important for their activation and maturation.
What is a HapMap sample?
The aim of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome, by characterizing sequence variants, their frequencies, and correlations between them, in DNA samples from populations with ancestry from parts of Africa, Asia and Europe.