What is SonoVue contrast?
4.1 SonoVue is a second-generation contrast agent that uses sulphur hexafluoride microbubbles for contrast-enhanced ultrasound imaging in adults. SonoVue is a low solubility gas contrast agent that allows imaging at low mechanical index, which leads to effective suppression of the tissue signal.
Who makes SonoVue?
Bracco International B.V.
Authorisation details
| Publication details | |
|---|---|
| Marketing-authorisation holder | Bracco International B.V. |
| Revision | 19 |
| Date of issue of marketing authorisation valid throughout the European Union | 26/03/2001 |
| Contact address | Strawinskylaan 3051 NL – 1077 ZX Amsterdam The Netherlands |
What is SonoVue?
SonoVue is a transpulmonary echocardiographic contrast agent for use in adult patients with suspected or established cardiovascular disease to provide opacification of cardiac chambers and enhance left ventricular endocardial border delineation. Doppler of macrovasculature.
How does contrast enhanced ultrasound work?
The contrast agent in CEUS contains tiny, gas-filled microbubbles. The bubbles are smaller than the size of your blood cells. When sound waves from the ultrasound meet the contrast bubbles the bubbles vibrate and strongly reflect the sound waves. This creates a very light area in the image.
How do you use SonoVue?
Intravenous use SonoVue should be administered immediately after drawing into the syringe by injection into a peripheral vein. Every injection should be followed by a flush with 5 mL of sodium chloride 9 mg/mL (0.9%) solution for injection.
How do you make SonoVue?
SonoVue must be prepared before use by injecting through the septum 5 mL of sodium chloride 9 mg/mL (0.9%) solution for injection to the contents of the vial. The vial is then shaken vigorously for twenty seconds after which the desired volume of the dispersion can be drawn into a syringe as follows: 1.
How long does contrast ultrasound take?
The ultrasound gel does not usually stain or discolor clothing. The entire CEUS procedure will generally take 30-60 minutes. This time may vary depending on the number of lesions your doctor evaluates.
Is ultrasound contrast safe?
Ultrasound contrast agents are generally safe. The ultrasound scanning time and the acoustic output should be kept to the lowest level consistent with obtaining diagnostic information. Adverse reactions should be treated symptomatically.
What contrast media is used in ultrasound?
SonoVue is a purely intravascular contrast agent, therefore it allows assessment of the vascularity and non-specific contrast agent retention of lesions. Due to its widespread approval, it is by far the most commonly utilized ultrasound contrast agent currently.
Is optison a blood product?
Optison is classified as a medical imaging drug product by the FDA; it is not a blood product, even though the microsphere shell is made from a naturally occurring blood protein, albumin. In 2021, the FDA removed the hypersensitivity to blood and blood products contraindication for Optison.
How do I give optison?
OPTISON is administered via an intravenous injection to allow the microspheres to enter the heart chamber and fill the left heart chamber. OPTISON is injected during the ultrasound examination in order to allow the doctor to assess the function of your heart. The recommended dose is 0.5 ml – 3.0 ml per patient.
Can I eat before an ultrasound?
Adults: Do not eat or drink eight hours before exam. Children: Do not eat or drink four hours before study or skip one meal. Take medications with a small sip of water.
How long does a contrast ultrasound take?
Once the imaging is complete, the sonographer will wipe the clear ultrasound gel off your skin. The ultrasound gel does not usually stain or discolor clothing. The entire CEUS procedure will generally take 30-60 minutes. This time may vary depending on the number of lesions your doctor evaluates.
What are the two types of contrast media?
Contrast agents can be classified into two broad groups, depending on their interaction with x-radiation—positive contrast agents (radiopaque) and negative contrast agents (radiolucent).
What is optison used for?
OPTISON is a transpulmonary echocardiographic contrast agent for use in patients with suspected or established cardiovascular disease to provide opacification of cardiac chambers, enhance left ventricular endocardial border delineation with resulting improvement in wall motion visualisation.
Does optison have albumin?
Optison is not recommended for use at mechanical indices greater than 0.8. This product contains albumin, a derivative of human blood. Based on effective donor screening and product manufacturing processes, it carries an extremely remote risk for transmission of viral disease.