Why do we use BALB c mice?
BALB/cJ mice are frequently used for a variety of immunological studies, in part because they demonstrate TH2-biased immune responses. BALB/c mice are particularly well known for the production of plasmacytoma on injection with mineral oil, forming the basis for the production of monoclonal antibodies.
How long do BALB c mice live?
The longitudinal study has been performed on 88 male mice, checking individually their body weight and date of death and analyzing survival data by a model built by our own. Survival analysis shows quite higher longevity (median age: about 29 months) in this population when compared with other BALB/c strains.
Why we use inbred BALB c mice for making monoclonal antibodies?
BALB/c Mice Details Their ability to produce plasma cell tumors within soft tissue is important in the production of monoclonal antibodies (mAbs). With BALB/c mice, Th2 cells are easily triggered by immunization, meaning this mouse strain is an exceptional responder to immunization.
Why BALB c mice are used for antibody production?
How much is a BALB c mouse?
BALB Males
| Age in Weeks | Quantity | |
|---|---|---|
| 1-199 | 200-999 | |
| 3 to 4 | $27.00 | $25.00 |
| 5 to 6 | $32.00 | $29.00 |
| 7 to 8 | $36.00 | $32.00 |
Are BALB c mice wild type?
BALB/c wild-type mice were obtained from the Walter and Eliza Hall Institute for Medical Research and were maintained at the Peter MacCallum Cancer Centre. All experiments were approved by the Peter MacCallum Cancer Centre Animal Ethics Committee.
Are BALB c mice transgenic?
BALB/c is one of the most widely used and best characterized mouse strains in immunology. For various applications, it is necessary to generate BALB/c transgenic mice.
Is BALB c mouse germ free?
Germ Free BALB/c Taconic is the only commercial provider of germ-free BALB/c mice.
What is the difference between TH1 and Th2 response?
TH1 immune response refers to the cytokine-mediated immune response generated by TH1 cells against intracellular parasites such as bacteria and virus, while TH2 immune response refers to the cytokine-mediated immune response generated by TH2 cells against large, extracellular parasites such as helminths.
What are TH1 and Th2 cells?
Th1 cells mainly develop following infections by intracellular bacteria and some viruses, whereas Th2 cells predominate in response to infestations by gastrointestinal nematodes.
Why are ICR mice used?
Institute of Cancer Research (ICR) mice have been widely used in various research fields including toxicology, oncology, pharmacology, and pharmaceutical product safety testing for decades.
What are outbred mice?
Breeding outbred stocks Like inbred mouse strains, outbred mouse stocks have an official definition: “a closed population (for at least four generations) of genetically variable animals that is bred to maintain maximum heterozygosity”2. The goal in maintaining an outbred stock is usually to minimize genetic change.
What is the meaning of BALB/c?
BALB/c. BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived.
What is the history of BALB/c substrains?
By 1935 the animals were in the possession of Muller’s student, George Davis Snell, who moved them to The Jackson Laboratory. This stock provided the basis of all the BALB/c substrains that are now in use around the world. Snell provided some animals from this stock to the National Institutes of Health (NIH) to maintain.
What is the use of BALB/c mouse in immunology?
The BALB/c mouse is among the most widely used inbred models used in biomedical research, and is particularly utilized in immunology and infectious disease research. Their ability to produce plasma cell tumors within soft tissue is important in the production of monoclonal antibodies (mAbs).
What kind of animal is a BALB c mouse?
BALB/c. BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived. Now over 200 generations from New York in 1920, BALB/c mice are distributed globally, and are among the most widely used inbred strains used in animal experimentation.