Where can I find transcription factor binding sites?
Go to Eukaryotic Promoter database, put in the NCBI accession number for your gene of interest and then search for the transcription factors of your interest for that promoter sequence. Promoter sequence can also be limited (eg. -500 to +100) or extended (-1000 to +1) the way you like.
What is Ets binding site?
The ETS Domain This motif is composed of 85 amino acids and forms a winged helix–turn–helix tertiary structure. The ETS domain allows Ets proteins to interact with an approximately 10-bp-long DNA element containing a GGAA/T central core, termed the Ets-binding site (EBS).
What is ETS fusion?
The fusion of the genes ERG and TMPRSS2 is the most frequent genomic alteration in prostate cancer. ERG is an oncogene that encodes a member of the family of ETS transcription factors. At lower frequency, other members of this gene family are also rearranged and overexpressed in prostate cancer.
What does ETS stand for and where it is found in biology?
Answer : Electron transmitter system, inner membrane of mitochondria.
What does Tfbs mean?
|TFBS||Transcription Factor Binding Sites|
Can transcription happen without TATA box?
From this original mutation study, a change in transcription can be seen when there is no TATA box to promote transcription, but transcription of a gene will occur when there is an insertion to the sequence.
What does ETS stand for in biology?
ETS or Electron Transport System is located in the inner mitochondrial membrane.
What do you understand about ETS How is it harmful give two instance?
The health hazards due to exposure to environmental tobacco smoke (ETS) are increasingly established. ETS contains thousands of chemicals including 43 known carcinogens. Known health effects of ETS exposure are lung cancer in nonsmokers, childhood disorders such as bronchitis, and perhaps, heart disease.
What do you understand about ETS How is it harmful?
In infants and young children, ETS increases the risk of pneumonia, bronchitis, bronchiolitis and fluid in the middle ear. In asthmatic children, ETS increases the severity and frequency of asthma attacks. Furthermore, as with active smoking, ETS reduces birth weight in the offspring of nonsmoking mothers.
How do you search for transcription factor binding sites?
MatInspector: Search for transcription factor binding sites. Introduction. MatInspector is a software tool that utilizes a large library of matrix descriptions for transcription factor binding sites to locate matches in DNA sequences. MatInspector is almost as fast as a search for IUPAC strings but has been shown to produce superior results.
How do I find transcription factors of a specific gene?
At the bottom, click on “View More Transcription Factors” you will get a complete list. Go to Eukaryotic Promoter database, put in the NCBI accession number for your gene of interest and then search for the transcription factors of your interest for that promoter sequence.
Where can I find the TFBS data from genehancer?
It does not only list TFBSs (list of TFs is given; to expand the list, click on the Plus sign on the top corner of each cell), but also the genes targeted by the same promoter/enhancer. Complete GeneHancer data (for all genes) can be downloaded by following the link at the bottom of the table.
How do I enter a transcription factor in MatInspector?
You can either enter the name of a transcription factor or the name of a matrix / matrix family from the current MatInspector library. If you enter a transcription factor (e.g. SP1) you will receive the GeneIDs of the corresponding genes and the matrix families that represent the DNA binding site of this transcription factor.