How is daptomycin dosed?
Dosage In Adults For cSSSI Administer CUBICIN 4 mg/kg to adult patients intravenously in 0.9% sodium chloride injection once every 24 hours for 7 to 14 days.
How often is daptomycin IV given?
CUBICIN 6 mg/kg should be administered intravenously in 0.9% sodium chloride injection once every 24 hours for 2 to 6 weeks. There are limited safety data for the use of CUBICIN for more than 28 days of therapy.
How long is a course of daptomycin?
In the paediatric SAB study, the mean duration of IV Daptomycin was 12 days, with a range of 1 to 44 days. The duration of therapy should be in accordance with available official recommendations. cSSTI = complicated skin and soft-tissue infections; SAB = S.
How do you take IV daptomycin?
A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed into one of your veins. This medicine may be injected for 2 minutes (in adults only) or it may be given slowly, so the needle will have to remain in place for up to 60 minutes.
What weight do you use for daptomycin dosing?
For bactericidal effect, free daptomycin concentrations should average two to four times the MIC over a 24-h period. When obtaining Food and Drug Administration (FDA) approval, daptomycin was dosed at 4–6 mg/kg of actual body weight (ABW) based on indication.
Why daptomycin is given once daily?
Daptomycin should be administered intravenously once daily, because adverse effects on skeletal muscle associated with an increase in plasma levels of creatine phosphokinase and myopathy were observed more frequently at shorter dosing intervals.
What happens if you take too much daptomycin?
Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms. A very serious allergic reaction to this drug is rare.
What should I monitor while on daptomycin?
Patients should also receive monitoring for muscle pain or weakness, new-onset or worsening peripheral neuropathy, and signs or symptoms of eosinophilic pneumonia. [14][18] Furthermore, patients who develop diarrhea should have testing for C. difficile infection.
What should I monitor when on daptomycin?
Because daptomycin can cause reversible skeletal myopathy, patients should be monitored for muscle pain or weakness, and serum creatine kinase levels should be checked weekly.
Is daptomycin dosing based on adjusted body weight?
Food and Drug Administration–approved daptomycin dosing uses actual body weight, despite limited dosing information for obese patients. Studies report alterations in daptomycin pharmacokinetics and creatine phosphokinase elevations associated with higher weight-based doses required for obese patients.
What should I monitor with daptomycin?
Patients receiving daptomycin should be monitored for the development of muscle pain or weakness. Consideration should be given to temporarily suspending agents associated with rhabdomyolysis.
Can you overdose on daptomycin?
Yes, like many other drugs, daptomycin (Cubicin) can be overdosed. If you think an overdose has occurred with the antibiotic daptomycin, seek immediate medical attention and call your local poison control center or call the National Poison Control Center at 1-800-222-1222.
How often do you check CPK with daptomycin?
Patient’s receiving daptomycin therapy should have CPK levels drawn weekly. Daptomycin should be discontinued in patients with symptoms of muscle pain or weakness whose CPK levels exceed 1000 U/L (~ 5x ULN), or in patients without symptoms whose CPK exceeds 10x ULN.
When should you not take daptomycin?
This medication is an antibiotic used to treat serious bacterial infections. It works by stopping the growth of bacteria. This medication is not recommended for use in children younger than 12 months due to possible risk of serious side effects.
Is daptomycin hard on the kidneys?
This medicine may cause serious skin reactions, including drug reaction with eosinophilia and systemic symptoms (DRESS), which can damage organs, including the liver, kidney, or heart.
Why do you monitor CPK for daptomycin?
Daptomycin is associated with elevations in CPK. We recommend a baseline CPK level and more frequent monitoring in patients with additional risks including renal impairment, critically ill patients unable to report symptoms of myopathy, and obese renally impaired patients.
At what CK do you stop daptomycin?
Daptomycin should be discontinued in patients with symptoms of muscle pain or weakness whose CPK levels exceed 1000 U/L (~ 5x ULN), or in patients without symptoms whose CPK exceeds 10x ULN.
Does daptomycin make you tired?
Call your doctor right away if you develop chest pain, dry cough, fever, general feeling of tiredness or weakness, rapid breathing, trouble breathing, or skin rash after receiving this medicine.
How often do you check CK on daptomycin?
Does daptomycin cause insomnia?
trouble sleeping (insomnia), anxiety, itching or skin rash, increased sweating, or.
How to dose daptomycin?
approved dosing recommendations for daptomycin are 4 mg/kg once every 24 hours when treating complicated skin and skin structure infections (cSSSI) and 6 mg/kg once every 24 hours when treating S. aureus bacteremia, however recent literature recommends doses as high as 8 – 12 mg/kg
Is daptomycin a penicillin medication?
No drug references linked in this topic. Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp [ 1,2 ].
When to stop daptomycin CPK?
the manufacturer recommends discontinuation of therapy in patients experiencing myopathy in conjunction with ck elevations (approximately 5 times the upper limit of normal [uln]) or in patients without symptoms who have increases in ck levels of ≥10 times the uln. 5 many clinicians discontinue daptomycin if the patient experiences any ck …
How to administer daptomycin?
To minimize foaming,AVOID vigorous agitation or shaking of the vial during or after reconstitution.