How is p27 degraded?
Degradation of p27 is a critical event for the G1/S transition and occurs through ubiquitination by SCFSkp2 and subsequent degradation by the 26S-proteasome.
How is p21 degraded?
CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2 Pathway during S Phase and after UV Irradiation.
Where is p27 found?
In proliferating cells p27 is prevalently bound to cyclin D/CDKs, whereas in G1-arrested cells p27 is found in complexes with cyclin E/CDK2.
Does p53 inhibit p21?
Abstract. In many cell types, p53-mediated growth inhibition is dependent on induction of p21, which is an inhibitor of cyclin-dependent kinases that are required for cell cycle progression. Failure of mutant p53 proteins to transactivate p21 may lead to uncontrolled proliferation.
What is role of p53 and p21?
p53/p21 in control of the G2/M cell–cycle checkpoint. The p53 and p21 tumor-suppressor proteins can help to sustain a G2/M cell–cycle arrest in response to stress (eg, DNA damage). The stress-induced stabilization of p53 triggers an increased expression of p21.
What is p27?
Project 27 (known as P27) aims to establish a single pan-Nordic payment infrastructure for the 27 million inhabitants of the region. The new payments infrastructure will be a world’s first and create the foundation for multiple initiatives and innovations in the Nordics.
Does Skp2 bind to p27?
Figure 1: Binding of phosphorylated p27 to SKP2. Figure 2: In vivo binding of SKP2 to p27. Figure 3: SKP2 and cyclin E–CDK2 are rate limiting for p27 ubiquitination in G1 extracts.
Why is p27 degraded by cyclin-dependent kinase?
Degradation of the mammalian cyclin-dependent kinase (CDK) inhibitor p27 is required for the cellular transition from quiescence to the proliferative state. The ubiquitination and subsequent degradation of p27 depend on its phosphorylation by cyclin–CDK complexes.
Does JAB1 co-purify with skp2-mediated ubiquitin-mediated degradation of p27?
At the moment, the relationship between SKP2-dependent ubiquitin-mediated degradation and Jab1-dependent degradation of p27 is not clear. Results of an initial fractionation study indicate that Jab1 does not co-purify with p27-ubiquitinating activities (our unpublished observations).
What is skp2/p27 axis in chronic nephropathy?
Roles of the Skp2/p27 axis in the progression of chronic nephropathy S-phase kinase-associated protein 2 (Skp2) is an F-box protein component of the Skp/Cullin/F-box-type E3 ubiquitin ligase that targets several cell cycle regulatory proteins for degradation through the ubiquitin-dependent pathway.
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